Detalhe da pesquisa
1.
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug.
Biotechnol Lett
; 43(1): 203-211, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851465
2.
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents.
Molecules
; 26(11)2021 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206005
3.
Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol.
Bioorg Med Chem Lett
; 30(11): 127135, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229061
4.
Synthesis and antiproliferative activity of C- and N-terminal analogues of culicinin D.
Bioorg Med Chem Lett
; 30(16): 127331, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631536
5.
Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Molecules
; 25(21)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105798
6.
New Promise and Opportunities for Allosteric Kinase Inhibitors.
Angew Chem Int Ed Engl
; 59(33): 13764-13776, 2020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31889388
7.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
8.
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study.
Bioorg Med Chem Lett
; 29(10): 1215-1219, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885680
9.
Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry.
Med Res Rev
; 38(5): 1550-1581, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29377179
10.
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Biochem J
; 471(2): 131-53, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26431849
11.
Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.
J Struct Biol
; 192(3): 539-544, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522274
12.
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
J Biol Chem
; 288(52): 37138-53, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196959
13.
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.
Chin J Cancer
; 33(2): 80-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845143
14.
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
J Med Chem
; 67(4): 2667-2689, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348819
15.
Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions.
Bioorg Med Chem
; 21(24): 7971-80, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436995
16.
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
J Med Chem
; 66(17): 11656-11671, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669428
17.
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506.
ACS Med Chem Lett
; 14(11): 1517-1523, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974941
18.
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov).
J Med Chem
; 66(11): 7405-7420, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37220641
19.
Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors.
J Med Chem
; 65(1): 58-83, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34962782
20.
Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling.
Front Pharmacol
; 13: 803602, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35211015